› 2arw

Solution NMR

The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor

Released:
DOI: 10.2210/pdb2arw/pdb
PDB entry 2arw coloured by chain, front view.
PDB entry 2arw coloured by chain, side view.
PDB entry 2arw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the membrane-proximal cytokine receptor domain of the human interleukin-6 receptor.
Hecht O, Dingley AJ, Schwanter A, Ozbek S, Rose-John S, Grötzinger J
Biol Chem 387 1255-9 (2006)
PMID: 16972794

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140410 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Soluble interleukin-6 receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P08887 (Residues: 212-336; Coverage: 28%)
Gene name: IL6R
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: torsion angle dynamicsu
Expression system: Escherichia coli BL21

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Citations

1 review citation

The "thrifty" gene encoding Ahsg/Fetuin-A meets the insulin receptor: Insights into the mechanism of insulin resistance.
Goustin et al. (2011)
3 other articles

2 mentions without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)
1 more