X-ray diffraction
2.5Å resolution

Structural Basis of DNA Recognition by p53 Tetramers (complex IV)

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Cellular tumor antigen p53 Chains: A, B
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 22.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P04637 (Residues: 94-293; Coverage: 51%)
Gene names: P53, TP53
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
5'-D(*CP*GP*GP*AP*CP*AP*TP*GP*TP*CP*CP*G)-3' Chains: E, F
Molecule details ›
Chains: E, F
Length: 12 nucleotides
Theoretical weight: 3.66 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: C2
Unit cell:
a: 91.997Å b: 67.903Å c: 74.989Å
α: 90° β: 92.97° γ: 90°
R R work R free
0.169 0.164 0.251
Expression systems:
  • Escherichia coli
  • Not provided