› 2adl

Solution NMR

Solution structure of the bacterial antitoxin CcdA: Implications for DNA and toxin binding

Released:
DOI: 10.2210/pdb2adl/pdb
PDB entry 2adl coloured by chain, front view.
PDB entry 2adl coloured by chain, side view.
PDB entry 2adl coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA.
Madl T, Van Melderen L, Mine N, Respondek M, Oberer M, Keller W, Khatai L, Zangger K
J Mol Biol 364 170-85 (2006)
PMID: 17007877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Antitoxin CcdA Chains: A, B
Molecule details ›
Chains: A, B
Length: 72 amino acids
Theoretical weight: 8.41 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P62552 (Residues: 1-72; Coverage: 100%)
Gene names: ECOK12F042, H, ccdA, letA
Sequence domains: Post-segregation antitoxin CcdA
Structure domains: Arc Repressor Mutant

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Toxin-antitoxin systems in bacteria and archaea.
Yamaguchi et al. (2011)
15 more

3 mentions without citation

Wake me when it's over - Bacterial toxin-antitoxin proteins and induced dormancy.
Coussens et al. (2016)
2 more