› 1zsv

X-ray diffraction
2.3Å resolution

Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase

Released:
DOI: 10.2210/pdb1zsv/pdb
PDB entry 1zsv coloured by chain, front view.
PDB entry 1zsv coloured by chain, side view.
PDB entry 1zsv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Turnbull AP, Johansson C, Savitsky P, Guo K, Edwards A, Arrowsmith C, Sundstrom M, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reactions catalysed: 
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11-alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H
A n-alkanal + NAD(P)(+) = an alk-2-enal + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-172121 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Prostaglandin reductase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 349 amino acids
Theoretical weight: 38.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14914 (Residues: 4-329; Coverage: 99%)
Gene names: LTB4DH, PTGR1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CL 22 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P43
Unit cell:
a: 92.543Å b: 92.543Å c: 202.77Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.249
Expression system: Escherichia coli

Quick links