Function and Biology

Structure-based evaluation of selective and non-selective small molecules that block HIV-1 TAT and PCAF association

Source organism: Homo sapiens
Biochemical function: histone acetyltransferase activity
Biological process: not assigned
Cellular component: not assigned

EC 2.3.1.57: Diamine N-acetyltransferase

Reaction catalysed:
Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine
Systematic name:
Acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase
Alternative Name(s):
  • Acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase
  • Diamine acetyltransferase
  • Putrescine (diamine)-acetylating enzyme
  • Putrescine N-acetyltransferase
  • Putrescine acetylase
  • Putrescine acetyltransferase
  • Spermidine N(1)-acetyltransferase
  • Spermidine acetyltransferase
  • Spermidine/spermine N(1)-acetyltransferase

EC 2.3.1.48: Histone acetyltransferase

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine
Systematic name:
Acetyl-CoA:[protein]-L-lysine acetyltransferase
Alternative Name(s):
  • Acetyl-CoA:histone acetyltransferase
  • Histone acetokinase
  • Histone acetylase
  • Histone transacetylase
  • Lysine acetyltransferase
  • Nucleosome-histone acetyltransferase
  • Protein lysine acetyltransferase

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. Histone acetyltransferase KAT2B
The deposited structure of PDB entry 1zs5 contains 1 copy of Pfam domain PF00439 (Bromodomain) in Histone acetyltransferase KAT2B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Histone acetyltransferase KAT2B
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Histone acetyltransferase KAT2B
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Histone acetyltransferase KAT2B
IPR037800
Domain description: Histone acetyltransferase GCN5
Occurring in:
  1. Histone acetyltransferase KAT2B

Structure domain

CATH CATH domain
1.20.920.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Histone Acetyltransferase; Chain A
Homology: Bromodomain-like
Occurring in:
  1. Histone acetyltransferase KAT2B
The deposited structure of PDB entry 1zs5 contains 1 copy of CATH domain 1.20.920.10 (Histone Acetyltransferase; Chain A) in Histone acetyltransferase KAT2B. Showing 1 copy in chain A.
SCOP SCOP annotation
47371
Class: All alpha proteins
Fold: Bromodomain-like
Superfamily: Bromodomain
Occurring in:
  1. Histone acetyltransferase KAT2B
The deposited structure of PDB entry 1zs5 contains 1 copy of SCOP domain 47371 (Bromodomain) in Histone acetyltransferase KAT2B. Showing 1 copy in chain A.