1zr0

X-ray diffraction
1.8Å resolution

Crystal Structure of Kunitz Domain 1 of Tissue Factor Pathway Inhibitor-2 with Bovine Trypsin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cationic trypsin Chains: A, C
Molecule details ›
Chains: A, C
Length: 223 amino acids
Theoretical weight: 23.31 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P00760 (Residues: 24-246; Coverage: 97%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Tissue factor pathway inhibitor 2 Chains: B, D
Molecule details ›
Chains: B, D
Length: 63 amino acids
Theoretical weight: 7.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P48307 (Residues: 28-90; Coverage: 30%)
Gene name: TFPI2
Sequence domains: Kunitz/Bovine pancreatic trypsin inhibitor domain
Structure domains: Pancreatic trypsin inhibitor Kunitz domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P212121
Unit cell:
a: 74.107Å b: 77.013Å c: 125.424Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.296
Expression system: Escherichia coli