1zn9

X-ray diffraction
2.05Å resolution

Human Adenine Phosphoribosyltransferase in Apo and AMP Complexed Forms

Released:

Function and Biology Details

Reaction catalysed:
AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenine phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 180 amino acids
Theoretical weight: 19.63 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P07741 (Residues: 1-180; Coverage: 100%)
Gene name: APRT
Sequence domains: Phosphoribosyl transferase domain
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 47.511Å b: 49.252Å c: 140.105Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.151 0.225
Expression system: Escherichia coli BL21(DE3)