1za3

X-ray diffraction
3.35Å resolution

The crystal structure of the YSd1 Fab bound to DR5

Released:
Source organism: Homo sapiens
Primary publication:
Molecular recognition by a binary code.
J. Mol. Biol. 348 1153-62 (2005)
PMID: 15854651

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Fab-YSd1 light chain Chains: A, L
Molecule details ›
Chains: A, L
Length: 213 amino acids
Theoretical weight: 23.15 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Fab-YSd1 heavy chain Chains: B, H
Molecule details ›
Chains: B, H
Length: 236 amino acids
Theoretical weight: 25.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
Structure domains: Immunoglobulins
Tumor necrosis factor receptor superfamily member 10B Chains: R, S
Molecule details ›
Chains: R, S
Length: 134 amino acids
Theoretical weight: 14.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14763 (Residues: 54-183; Coverage: 33%)
Gene names: DR5, KILLER, TNFRSF10B, TRAILR2, TRICK2, UNQ160/PRO186, ZTNFR9
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P3221
Unit cell:
a: 147.059Å b: 147.059Å c: 144.947Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.224 0.28
Expression systems:
  • Not provided
  • Spodoptera frugiperda