1z8y

Electron Microscopy
9Å resolution

Mapping the E2 Glycoprotein of Alphaviruses

Released:

Function and Biology Details

Reaction catalysed:
Autocatalytic release of the core protein from the N-terminus of the togavirus structural polyprotein by hydrolysis of a -Trp-|-Ser- bond.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
hetero 1200-mer (preferred)
hetero icosamer
hetero 100-mer
hetero 120-mer
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein E1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 290 amino acids
Theoretical weight: 31.44 KDa
Source organism: Sindbis virus
UniProt:
  • Canonical: P03316 (Residues: 807-1096; Coverage: 23%)
Spike glycoprotein E1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 89 amino acids
Theoretical weight: 9.45 KDa
Source organism: Sindbis virus
UniProt:
  • Canonical: P03316 (Residues: 1101-1189; Coverage: 7%)
Spike glycoprotein E1 Chains: I, K, M, O
Molecule details ›
Chains: I, K, M, O
Length: 31 amino acids
Theoretical weight: 3.41 KDa
Source organism: Sindbis virus
UniProt:
  • Canonical: P03316 (Residues: 1215-1245; Coverage: 3%)
Spike glycoprotein E2 Chains: J, L, N, P
Molecule details ›
Chains: J, L, N, P
Length: 36 amino acids
Theoretical weight: 3.75 KDa
Source organism: Sindbis virus
UniProt:
  • Canonical: P03316 (Residues: 691-726; Coverage: 3%)
Capsid protein Chains: Q, R, S, T
Molecule details ›
Chains: Q, R, S, T
Length: 151 amino acids
Theoretical weight: 16.55 KDa
Source organism: Sindbis virus
UniProt:
  • Canonical: P03316 (Residues: 114-264; Coverage: 12%)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution:
Relevant EMDB volumes: EMD-1121