› 1z6u

X-ray diffraction
2.1Å resolution

Np95-like ring finger protein isoform b [Homo sapiens]

Released:
DOI: 10.2210/pdb1z6u/pdb
PDB entry 1z6u coloured by chain, front view.
PDB entry 1z6u coloured by chain, side view.
PDB entry 1z6u coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Walker JR, Avvakumov GV, Xue S, Newman EM, Mackenzie F, Sundstrom M, Arrowsmith C, Edwards A, Bochkarev A, Dhe-Paganon S, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188676 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase UHRF2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 17.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q96PU4 (Residues: 672-802; Coverage: 16%)
Gene names: NIRF, RNF107, UHRF2
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P41212
Unit cell:
a: 64.561Å b: 64.561Å c: 130.313Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.222 0.283
Expression system: Escherichia coli

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