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Structure of the D41N variant of the human mitochondrial deoxyribonucleotidase in complex with uridine 2'-monophosphate

Source organism: Homo sapiens
Biochemical function: 5'-nucleotidase activity
Biological process: deoxyribonucleotide catabolic process
Cellular component: not assigned

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GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF06941
Domain description: 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
The deposited structure of PDB entry 1z4j contains 1 copy of Pfam domain PF06941 (5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)) in 5'(3')-deoxyribonucleotidase, mitochondrial. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR023214
Domain description: HAD superfamily
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
IPR036412
Domain description: HAD-like superfamily
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
IPR010708
Domain description: 5'(3')-deoxyribonucleotidase
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial

Structure domains

CATH CATH domains
3.40.50.1000
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: HAD superfamily/HAD-like
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
The deposited structure of PDB entry 1z4j contains 1 copy of CATH domain 3.40.50.1000 (Rossmann fold) in 5'(3')-deoxyribonucleotidase, mitochondrial. Showing 1 copy in chain A.
1.10.40.40
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase Protein R1; domain 1
Homology: Deoxyribonucleotidase; domain 2
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
The deposited structure of PDB entry 1z4j contains 1 copy of CATH domain 1.10.40.40 (Ribonucleotide Reductase Protein R1; domain 1) in 5'(3')-deoxyribonucleotidase, mitochondrial. Showing 1 copy in chain A.
SCOP SCOP annotation
82382
Class: Alpha and beta proteins (a/b)
Fold: HAD-like
Superfamily: HAD-like
Occurring in:
  1. 5'(3')-deoxyribonucleotidase, mitochondrial
The deposited structure of PDB entry 1z4j contains 1 copy of SCOP domain 82382 (5'(3')-deoxyribonucleotidase (dNT-2)) in 5'(3')-deoxyribonucleotidase, mitochondrial. Showing 1 copy in chain A.

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