› 1z1c

X-ray diffraction
3.5Å resolution

Structural Determinants of Tissue Tropism and In Vivo Pathogenicity for the Parvovirus Minute virus of Mice

Released:
DOI: 10.2210/pdb1z1c/pdb
PDB entry 1z1c coloured by chain, front view.
PDB entry 1z1c coloured by chain, side view.
PDB entry 1z1c coloured by chain, top view.
Source organism: Murine minute virus (STRAIN MVMI)
Primary publication:
Structural determinants of tissue tropism and in vivo pathogenicity for the parvovirus minute virus of mice.
Kontou M, Govindasamy L, Nam HJ, Bryant N, Llamas-Saiz AL, Foces-Foces C, Hernando E, Rubio MP, McKenna R, Almendral JM, Agbandje-McKenna M
J Virol 79 10931-43 (2005)
PMID: 16103145

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114878 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Capsid protein VP1 Chain: A
Molecule details ›
Chain: A
Length: 587 amino acids
Theoretical weight: 64.75 KDa
Source organism: Murine minute virus (STRAIN MVMI)
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P07302 (Residues: 143-729; Coverage: 81%)
Sequence domains: Parvovirus coat protein VP2
Structure domains: Parvovirus coat protein VP1/VP2
5'-D(*AP*TP*CP*CP*TP*CP*TP*AP*TP*CP*AP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 12 nucleotides
Theoretical weight: 3.56 KDa
Source organism: Murine minute virus (STRAIN MVMI)
Expression system: Not provided
5'-D(*AP*CP*AP*CP*CP*AP*AP*AP*A)-3' Chain: C
Molecule details ›
Chain: C
Length: 9 nucleotides
Theoretical weight: 2.7 KDa
Source organism: Murine minute virus (STRAIN MVMI)
Expression system: Not provided

Ligands and Environments

2 bound ligands:
Ligand CA 2 x CA
Ligand D5M 1 x D5M
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: C2
Unit cell:
a: 448.7Å b: 416.7Å c: 305.3Å
α: 90° β: 95.8° γ: 90°
R-values:
R R work R free
0.325 0.325 0.329
Expression systems:
  • Spodoptera frugiperda
  • Not provided

Quick links

Citations

8 review citations

Twenty-Five Years of Structural Parvovirology.
Mietzsch et al. (2019)
7 more

12 mentions without citation

The regulation of mDia1 by autoinhibition and its release by Rho*GTP.
Lammers et al. (2005)
11 more