Structure analysis

Structure of GTP-Bound Rab4Q67L GTPase in complex with the central Rab binding domain of Rabenosyn-5

X-ray diffraction
1.92Å resolution
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
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Multimeric state: hetero dimer
Accessible surface area: 10600 Å2
Buried surface area: 2700 Å2
Dissociation area: 900 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 11 kcal/mol
Interface energy (ΔGint): -21 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
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Multimeric state: hetero dimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, C
Length: 172 amino acids
Theoretical weight: 19.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P20338 (Residues: 7-177; Coverage: 78%)
Gene names: RAB4, RAB4A
Pfam: Ras family
InterPro:
CATH: P-loop containing nucleotide triphosphate hydrolases
SCOP: G proteins

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Chains: B, D
Length: 69 amino acids
Theoretical weight: 7.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H1K0 (Residues: 440-503; Coverage: 8%)
Gene names: RBSN, ZFYVE20
Pfam: Rabenosyn Rab binding domain
InterPro:
CATH: Rabenosyn, Rab binding domain
SCOP: Rabenosyn-5 Rab-binding domain-like

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