X-ray diffraction
1.32Å resolution

Structure of GTP-Bound Rab22Q64L GTPase in complex with the minimal Rab binding domain of Rabenosyn-5


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ras-related protein Rab-22A Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 19.18 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: P35285 (Residues: 2-169; Coverage: 87%)
Gene names: Rab22, Rab22a
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases
Rabenosyn-5 Chain: B
Molecule details ›
Chain: B
Length: 59 amino acids
Theoretical weight: 6.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q9H1K0 (Residues: 728-784; Coverage: 7%)
Gene names: RBSN, ZFYVE20
Sequence domains: Rabenosyn Rab binding domain
Structure domains: Rabenosyn, Rab binding domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 45.075Å b: 55.897Å c: 85.96Å
α: 90° β: 90° γ: 90°
R R work R free
0.206 0.214 0.235
Expression system: Escherichia coli