› 1yxv

X-ray diffraction
2Å resolution

Crystal Structure of Kinase Pim1 in complex with 3,4-Dihydroxy-1-methylquinolin-2(1H)-one

Released:
DOI: 10.2210/pdb1yxv/pdb
PDB 1yxv coloured by chain and viewed from the front.
PDB 1yxv coloured by chain and viewed from the side.
PDB 1yxv coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Crystal structures of proto-oncogene kinase Pim1: a target of aberrant somatic hypermutations in diffuse large cell lymphoma.
Kumar A, Mandiyan V, Suzuki Y, Zhang C, Rice J, Tsai J, Artis DR, Ibrahim P, Bremer R
J. Mol. Biol. 348 183-93 (2005)
PMID: 15808862

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 293 amino acids
Theoretical weight: 33.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 29-313; Coverage: 91%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand IMD 1 x IMD
Ligand LI6 1 x LI6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P65
Unit cell:
a: 96.592Å b: 96.592Å c: 80.556Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.188 0.211
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?
Amin et al. (2017)
17 more

2 mentions without citation

Identification of the first inhibitor of the GBP1:PIM1 interaction. Implications for the development of a new class of anticancer agents against paclitaxel resistant cancer cells.
Andreoli et al. (2014)
1 more