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Structural basis of swinholide A binding to actin.

Klenchin VA, King R, Tanaka J, Marriott G, Rayment I
Chem Biol 12 287-91 (2005)
Cited: 43 times
EuropePMC logo PMID: 15797212

Abstract

Marine toxins targeting the actin cytoskeleton represent a new and promising class of anti-cancer compounds. Here we present a 2.0 A resolution structure of swinholide A, a marine macrolide, bound to two actin molecules. The structure demonstrates that the actin dimer in the complex does not represent a physiologically relevant entity, for the two actin molecules do not interact with each other. The swinholide A actin binding site is the same as that targeted by toxins of the trisoxazole family and numerous actin binding proteins, highlighting the importance of this site in actin polymerization. The observed structure reveals the mechanism of action of swinholide A and provides a structural framework about which to design new agents directed at the cytoskeleton.

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  7. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. Lin SM, Lin SC, Hsu JN, Chang CK, Chien CM, Wang YS, Wu HY, Jeng US, Kehn-Hall K, Hou MH. J Med Chem 63 3131-3141 (2020)
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  10. Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A. Kita M, Hirayama Y, Sugiyama M, Kigoshi H. Angew. Chem. Int. Ed. Engl. 50 9871-9874 (2011)
  11. Isoswinholide B and swinholide K, potently cytotoxic dimeric macrolides from Theonella swinhoei. Sinisi A, Calcinai B, Cerrano C, Dien HA, Zampella A, D'Amore C, Renga B, Fiorucci S, Taglialatela-Scafati O. Bioorg. Med. Chem. 21 5332-5338 (2013)
  12. Structural and biochemical studies of actin in complex with synthetic macrolide tail analogues. Pereira JH, Petchprayoon C, Hoepker AC, Moriarty NW, Fink SJ, Cecere G, Paterson I, Adams PD, Marriott G. ChemMedChem 9 2286-2293 (2014)
  13. Actin-Dynamics in Plant Cells: The Function of Actin-Perturbing Substances: Jasplakinolide, Chondramides, Phalloidin, Cytochalasins, and Latrunculins. Holzinger A, Blaas K. Methods Mol. Biol. 1365 243-261 (2016)
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  15. Binding of Red Clover Isoflavones to Actin as A Potential Mechanism of Anti-Metastatic Activity Restricting the Migration of Cancer Cells. Budryn G, Grzelczyk J, Pérez-Sánchez H. Molecules 23 (2018)
  16. Actin Isoform Composition and Binding Factors Fine-Tune Regulatory Impact of Mical Enzymes. Martin JL, Khan A, Grintsevich EE. Int J Mol Sci 24 16651 (2023)
  17. Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives. Tee YH, Goh WJ, Yong X, Ong HT, Hu J, Tay IYY, Shi S, Jalal S, Barnett SFH, Kanchanawong P, Huang W, Yan J, Lim YAB, Thiagarajan V, Mogilner A, Bershadsky AD. Nat Commun 14 776 (2023)
  18. Development of a novel inducer of protein-protein interactions based on aplyronine A. Ohyoshi T, Takano A, Namiki M, Ogura T, Miyazaki Y, Ebihara Y, Takeno K, Hayakawa I, Kigoshi H. Chem. Commun. (Camb.) 54 9537-9540 (2018)
  19. Equatorial Assembly of the Cell-Division Actomyosin Ring in the Absence of Cytokinetic Spatial Cues. Lim TC, Hatano T, Kamnev A, Balasubramanian MK, Chew TG. Curr. Biol. 28 955-962.e3 (2018)
  20. Influencing the Actin Dynamics in Plant Cells by Jasplakinolide, Chondramides, Phalloidin, Cytochalasins, and Latrunculins. Holzinger A. Methods Mol Biol 2364 177-198 (2022)
  21. Molecular dynamics and high throughput binding free energy calculation of anti-actin anticancer drugs-New insights for better design. L R, R PK, M M SM. Comput Biol Chem 64 47-55 (2016)
  22. PHACTR1 promotes the mobility of papillary thyroid carcinoma cells by inducing F-actin formation. Zang L, Song Y, Tian Y, Hu N. Heliyon 9 e20461 (2023)
  23. Pointed-end processive elongation of actin filaments by Vibrio effectors VopF and VopL. Kudryashova E, Ankita, Ulrichs H, Shekhar S, Kudryashov DS. Sci Adv 8 eadc9239 (2022)
  24. Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein-Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1-C9 Macrolactone Part and the C24-C34 Side Chain. Futaki K, Takahashi M, Tanabe K, Fujieda A, Kigoshi H, Kita M. ACS Omega 4 8598-8613 (2019)
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