PDBe 1yoj

X-ray diffraction
1.95Å resolution

Crystal structure of Src kinase domain


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Proto-oncogene tyrosine-protein kinase Src Chains: A, B
Molecule details ›
Chains: A, B
Length: 283 amino acids
Theoretical weight: 32.45 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P12931 (Residues: 254-536; Coverage: 53%)
Gene names: SRC, SRC1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P1
Unit cell:
a: 41.867Å b: 62.542Å c: 73.902Å
α: 100.52° β: 88.88° γ: 89.99°
R R work R free
0.216 0.214 0.258
Expression system: Spodoptera frugiperda