› › Function and Biology

The active form of phosphoglycerate dehydrogenase

Source organism: Escherichia coli
Biochemical function: serine binding
Biological process: L-serine biosynthetic process
Cellular component: cytosol

Quick links

EC 1.1.1.95: Phosphoglycerate dehydrogenase

Reaction catalysed:
3-phospho-D-glycerate + NAD(+) = 3-phosphonooxypyruvate + NADH
Systematic name:
3-phospho-D-glycerate:NAD(+) 2-oxidoreductase
Alternative Name(s):
  • 3-phosphoglycerate dehydrogenase
  • 3-phosphoglycerate:NAD(+) 2-oxidoreductase
  • 3-phosphoglyceric acid dehydrogenase
  • 3PHP reductase
  • Alpha-KG reductase
  • Alpha-phosphoglycerate dehydrogenase
  • D- and L-HGA
  • D-3-phosphoglycerate dehydrogenase
  • D-3-phosphoglycerate:NAD(+) oxidoreductase
  • Glycerate 3-phosphate dehydrogenase
  • Glycerate-1,3-phosphate dehydrogenase
  • PGDH
  • PHGDH (gene name)
  • Phosphoglycerate oxidoreductase
  • Phosphoglyceric acid dehydrogenase
  • SerA
  • SerA 3PG dehydrogenase

EC 1.1.1.399: 2-oxoglutarate reductase

Reaction catalysed:
(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH
Systematic name:
(R)-2-hydroxyglutarate,NAD(+) 2-oxidireductase
Alternative Name(s):
  • SerA (gene name)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF01842
Domain description: ACT domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of Pfam domain PF01842 (ACT domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.

PF02826
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of Pfam domain PF02826 (D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.

PF00389
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of Pfam domain PF00389 (D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR002912
Domain description: ACT domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR029753
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR045865
Domain description: ACT-like domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR029752
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site 1
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR006140
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
IPR006139
Domain description: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase

Structure domains

CATH CATH domains
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 8 copies of CATH domain 3.40.50.720 (Rossmann fold) in D-3-phosphoglycerate dehydrogenase. Showing 2 copies in chain A.
3.30.70.260
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Alpha-Beta Plaits
Homology: Alpha-Beta Plaits
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of CATH domain 3.30.70.260 (Alpha-Beta Plaits) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.
SCOP SCOP annotations
52284
Class: Alpha and beta proteins (a/b)
Fold: Flavodoxin-like
Superfamily: Formate/glycerate dehydrogenase catalytic domain-like
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of SCOP domain 52284 (Formate/glycerate dehydrogenases, substrate-binding domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.
55022
Class: Alpha and beta proteins (a+b)
Fold: Ferredoxin-like
Superfamily: ACT-like
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of SCOP domain 55022 (Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.
51830
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. D-3-phosphoglycerate dehydrogenase
The deposited structure of PDB entry 1yba contains 4 copies of SCOP domain 51830 (Formate/glycerate dehydrogenases, NAD-domain) in D-3-phosphoglycerate dehydrogenase. Showing 1 copy in chain A.

Quick links