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Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk.

Zou P, Pinotsis N, Lange S, Song YH, Popov A, Mavridis I, Mayans OM, Gautel M, Wilmanns M
Nature 439 229-33 (2006)
Cited: 112 times
EuropePMC logo PMID: 16407954

Abstract

The Z-disk of striated and cardiac muscle sarcomeres is one of the most densely packed cellular structures in eukaryotic cells. It provides the architectural framework for assembling and anchoring the largest known muscle filament systems by an extensive network of protein-protein interactions, requiring an extraordinary level of mechanical stability. Here we show, using X-ray crystallography, how the amino terminus of the longest filament component, the giant muscle protein titin, is assembled into an antiparallel (2:1) sandwich complex by the Z-disk ligand telethonin. The pseudosymmetric structure of telethonin mediates a unique palindromic arrangement of two titin filaments, a type of molecular assembly previously found only in protein-DNA complexes. We have confirmed its unique architecture in vivo by protein complementation assays, and in vitro by experiments using fluorescence resonance energy transfer. The model proposed may provide a molecular paradigm of how major sarcomeric filaments are crosslinked, anchored and aligned within complex cytoskeletal networks.

Reviews - 1ya5 mentioned but not cited (1)

  1. The ZT Biopolymer: A Self-Assembling Protein Scaffold for Stem Cell Applications. Nesterenko Y, Hill CJ, Fleming JR, Murray P, Mayans O. Int J Mol Sci 20 E4299 (2019)

Articles - 1ya5 mentioned but not cited (6)

  1. The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk. Bertz M, Wilmanns M, Rief M. Proc Natl Acad Sci U S A 106 13307-133310 (2009)
  2. Combination of Whole Genome Sequencing, Linkage, and Functional Studies Implicates a Missense Mutation in Titin as a Cause of Autosomal Dominant Cardiomyopathy With Features of Left Ventricular Noncompaction. Hastings R, de Villiers CP, Hooper C, Ormondroyd L, Pagnamenta A, Lise S, Salatino S, Knight SJ, Taylor JC, Thomson KL, Arnold L, Chatziefthimiou SD, Konarev PV, Wilmanns M, Ehler E, Ghisleni A, Gautel M, Blair E, Watkins H, Gehmlich K. Circ Cardiovasc Genet 9 426-435 (2016)
  3. The retinal specific CD147 Ig0 domain: from molecular structure to biological activity. Redzic JS, Armstrong GS, Isern NG, Jones DN, Kieft JS, Eisenmesser EZ. J Mol Biol 411 68-82 (2011)
  4. Influence of V54M mutation in giant muscle protein titin: a computational screening and molecular dynamics approach. Thirumal Kumar D, George Priya Doss C, Sneha P, Tayubi IA, Siva R, Chakraborty C, Magesh R. J Biomol Struct Dyn 35 917-928 (2017)
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Reviews citing this publication (44)

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Articles citing this publication (61)

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