X-ray diffraction
1.81Å resolution

Alcohol Dehydrogenase from Entamoeba histolotica in complex with cacodylate

Source organism: Entamoeba histolytica
Primary publication:
Structure of alcohol dehydrogenase from Entamoeba histolytica.
Acta Crystallogr. D Biol. Crystallogr. 62 541-7 (2006)
PMID: 16627948

Function and Biology Details

Reaction catalysed:
Propan-2-ol + NADP(+) = acetone + NADPH
Biochemical function:
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
NADP-dependent isopropanol dehydrogenase Chains: A, C
Molecule details ›
Chains: A, C
Length: 360 amino acids
Theoretical weight: 38.7 KDa
Source organism: Entamoeba histolytica
Expression system: Escherichia coli
  • Canonical: P35630 (Residues: 1-360; Coverage: 100%)
Gene name: ADH1
Sequence domains:
Structure domains:

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: C2221
Unit cell:
a: 76.891Å b: 234.139Å c: 96.241Å
α: 90° β: 90° γ: 90°
R R work R free
0.129 0.126 0.177
Expression system: Escherichia coli