1y96

X-ray diffraction
2Å resolution

crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Gem-associated protein 6 Chains: A, C
Molecule details ›
Chains: A, C
Length: 86 amino acids
Theoretical weight: 9.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WXD5 (Residues: 1-86; Coverage: 52%)
Gene name: GEMIN6
Structure domains: SH3 type barrels.
Gem-associated protein 7 Chains: B, D
Molecule details ›
Chains: B, D
Length: 85 amino acids
Theoretical weight: 9.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9H840 (Residues: 47-131; Coverage: 65%)
Gene name: GEMIN7
Sequence domains: Gem-associated protein 7 (Gemin7)
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P42212
Unit cell:
a: 136.011Å b: 136.011Å c: 81.515Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.252
Expression system: Escherichia coli BL21(DE3)