› 1y0x

X-ray diffraction
3.1Å resolution

Thyroxine-Thyroid Hormone Receptor Interactions

Released:
DOI: 10.2210/pdb1y0x/pdb
PDB entry 1y0x coloured by chain, front view.
PDB entry 1y0x coloured by chain, side view.
PDB entry 1y0x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Thyroxine-thyroid hormone receptor interactions.
Sandler B, Webb P, Apriletti JW, Huber BR, Togashi M, Cunha Lima ST, Juric S, Nilsson S, Wagner R, Fletterick RJ, Baxter JD
J Biol Chem 279 55801-8 (2004)
PMID: 15466465

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thyroid hormone receptor beta Chain: X
Molecule details ›
Chain: X
Length: 281 amino acids
Theoretical weight: 31.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10828 (Residues: 202-461; Coverage: 56%)
Gene names: ERBA2, NR1A2, THR1, THRB
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand CAC 6 x CAC
Ligand T44 1 x T44
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P3121
Unit cell:
a: 68.79Å b: 68.79Å c: 130.4Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.225 0.22 0.266
Expression system: Escherichia coli

Quick links

Citations

15 review citations

The Halogen Bond.
Cavallo et al. (2016)
14 more

1 mention without citation

Insight Into Molecular Determinants of T3 vs T4 Recognition From Mutations in Thyroid Hormone Receptor α and β.
Wejaphikul et al. (2019)