X-ray diffraction
1.8Å resolution

Crystal Structure of a FYVE-type domain from caspase regulator CARP2


Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
E3 ubiquitin-protein ligase rififylin Chain: A
Molecule details ›
Chain: A
Length: 120 amino acids
Theoretical weight: 13.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q8WZ73 (Residues: 26-145; Coverage: 33%)
Gene names: RFFL, RNF189, RNF34L
Structure domains: Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P31
Unit cell:
a: 51.196Å b: 51.196Å c: 38.564Å
α: 90° β: 90° γ: 120°
R R work R free
0.21 0.206 0.234
Expression system: Escherichia coli