Function and Biology

Structure of the GTP-binding protein TrmE from Thermotoga maritima complexed with 5-formyl-THF

Source organism: Thermotoga maritima
Biochemical function: GTP binding
Biological process: tRNA modification
Cellular component: cytosol

Sequence families

Pfam Protein families (Pfam)
PF10396
Domain description: GTP-binding protein TrmE N-terminus
Occurring in:
  1. tRNA modification GTPase MnmE
  2. tRNA modification GTPase MnmE
1 copy of Pfam domain PF10396 (GTP-binding protein TrmE N-terminus) in tRNA modification GTPase MnmE in PDB 1xzq.
2 copies of Pfam domain PF10396 (GTP-binding protein TrmE N-terminus) in tRNA modification GTPase MnmE in PDB 1xzq.

PF01926
Domain description: 50S ribosome-binding GTPase
Occurring in:
  1. tRNA modification GTPase MnmE
1 copy of Pfam domain PF01926 (50S ribosome-binding GTPase) in tRNA modification GTPase MnmE in PDB 1xzq.

InterPro InterPro annotations
IPR006073
Domain description: GTP binding domain
Occurring in:
  1. tRNA modification GTPase MnmE
IPR004520
Domain description: tRNA modification GTPase MnmE
Occurring in:
  1. tRNA modification GTPase MnmE
IPR018948
Domain description: GTP-binding protein TrmE, N-terminal
Occurring in:
  1. tRNA modification GTPase MnmE
  2. tRNA modification GTPase MnmE
IPR031168
Domain description: TrmE-type guanine nucleotide-binding domain
Occurring in:
  1. tRNA modification GTPase MnmE
IPR027266
Domain description: GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1
Occurring in:
  1. tRNA modification GTPase MnmE
  2. tRNA modification GTPase MnmE
IPR025867
Domain description: MnmE, helical domain
Occurring in:
  1. tRNA modification GTPase MnmE
IPR027417
Domain description: P-loop containing nucleoside triphosphate hydrolase
Occurring in:
  1. tRNA modification GTPase MnmE
IPR005225
Domain description: Small GTP-binding protein domain
Occurring in:
  1. tRNA modification GTPase MnmE
IPR008144
Domain description: Guanylate kinase-like domain
Occurring in:
  1. tRNA modification GTPase MnmE
IPR036393
Domain description: Acetylglutamate kinase-like superfamily
Occurring in:
  1. tRNA modification GTPase MnmE
IPR014729
Domain description: Rossmann-like alpha/beta/alpha sandwich fold
Occurring in:
  1. tRNA modification GTPase MnmE
IPR027368
Domain description: tRNA modification GTPase MnmE domain 2
Occurring in:
  1. tRNA modification GTPase MnmE

Structure domains

CATH CATH domains
3.30.1360.120
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Gyrase A; domain 2
Homology: Probable tRNA modification gtpase trme; domain 1
Occurring in:
  1. tRNA modification GTPase MnmE
  2. tRNA modification GTPase MnmE
1 copy of CATH domain 3.30.1360.120 (Gyrase A; domain 2) in tRNA modification GTPase MnmE in PDB 1xzq.
2 copies of CATH domain 3.30.1360.120 (Gyrase A; domain 2) in tRNA modification GTPase MnmE in PDB 1xzq.
1.20.120.430
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Four Helix Bundle (Hemerythrin (Met), subunit A)
Homology: tRNA modification GTPase MnmE domain 2
Occurring in:
  1. tRNA modification GTPase MnmE
1 copy of CATH domain 1.20.120.430 (Four Helix Bundle (Hemerythrin (Met), subunit A)) in tRNA modification GTPase MnmE in PDB 1xzq.
3.40.50.300
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: P-loop containing nucleotide triphosphate hydrolases
Occurring in:
  1. tRNA modification GTPase MnmE
1 copy of CATH domain 3.40.50.300 (Rossmann fold) in tRNA modification GTPase MnmE in PDB 1xzq.
SCOP SCOP annotations
116879
Class: All alpha proteins
Fold: Four-helical up-and-down bundle
Superfamily: TrmE connector domain
Occurring in:
  1. tRNA modification GTPase MnmE
1 copy of SCOP domain 116879 (TrmE connector domain) in tRNA modification GTPase MnmE in PDB 1xzq.
117997
Class: Alpha and beta proteins (a+b)
Fold: Folate-binding domain
Superfamily: Folate-binding domain
Occurring in:
  1. tRNA modification GTPase MnmE
  2. tRNA modification GTPase MnmE
1 copy of SCOP domain 117997 (TrmE formyl-THF-binding domain) in tRNA modification GTPase MnmE in PDB 1xzq.
2 copies of SCOP domain 117997 (TrmE formyl-THF-binding domain) in tRNA modification GTPase MnmE in PDB 1xzq.
52592
Class: Alpha and beta proteins (a/b)
Fold: P-loop containing nucleoside triphosphate hydrolases
Superfamily: P-loop containing nucleoside triphosphate hydrolases
Occurring in:
  1. tRNA modification GTPase MnmE
1 copy of SCOP domain 52592 (G proteins) in tRNA modification GTPase MnmE in PDB 1xzq.