› 1xwh

Solution NMR

NMR structure of the first phd finger of autoimmune regulator protein (AIRE1): insights into apeced

Released:
DOI: 10.2210/pdb1xwh/pdb
PDB entry 1xwh coloured by chain, ensemble of 20 models, front view.
PDB entry 1xwh coloured by chain, ensemble of 20 models, side view.
PDB entry 1xwh coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the first PHD finger of autoimmune regulator protein (AIRE1). Insights into autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) disease.
Bottomley MJ, Stier G, Pennacchini D, Legube G, Simon B, Akhtar A, Sattler M, Musco G
J Biol Chem 280 11505-12 (2005)
PMID: 15649886

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Autoimmune regulator Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O43918 (Residues: 293-354; Coverage: 11%)
Gene names: AIRE, APECED
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Structures were calculated using ARIA (1.2) in combination with CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

35 review citations

A central role for central tolerance.
Kyewski et al. (2006)
34 more

4 mentions without citation

PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus.
Musco et al. (2008)
3 more