1xwd

X-ray diffraction
2.92Å resolution

Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Glycoprotein hormones alpha chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 92 amino acids
Theoretical weight: 10.22 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01215 (Residues: 25-116; Coverage: 100%)
Gene name: CGA
Structure domains: Cystine-knot cytokines
Follitropin subunit beta Chains: B, E
Molecule details ›
Chains: B, E
Length: 111 amino acids
Theoretical weight: 12.5 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01225 (Residues: 19-129; Coverage: 100%)
Gene name: FSHB
Structure domains: Cystine-knot cytokines
Follicle-stimulating hormone receptor Chains: C, F
Molecule details ›
Chains: C, F
Length: 252 amino acids
Theoretical weight: 28.64 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P23945 (Residues: 17-268; Coverage: 37%)
Gene names: FSHR, LGR1
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: C2
Unit cell:
a: 121.33Å b: 66.938Å c: 148.629Å
α: 90° β: 99.13° γ: 90°
R-values:
R R work R free
0.221 0.219 0.259
Expression system: Trichoplusia ni