PDBe 1xw5

X-ray diffraction
1.8Å resolution

Human glutathione s-transferase M2-2 (E.C.2.5.1.18)complexed with glutathione, monoclinic crystal form

Released:
Source organism: Homo sapiens
Entry authors: Patskovska LN, Patskovsky YV, Almo SC, Listowsky I

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase Mu 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 217 amino acids
Theoretical weight: 25.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P28161 (Residues: 2-218; Coverage: 100%)
Gene names: GST4, GSTM2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand GSH 2 x GSH
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 51.2Å b: 49.79Å c: 92.04Å
α: 90° β: 94.27° γ: 90°
R-values:
R R work R free
0.22 0.206 0.232
Expression system: Escherichia coli BL21(DE3)