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Soluble methane monooxygenase hydroxylase-phenol soaked

Source organism: Methylococcus capsulatus
Biochemical function: methane monooxygenase NADPH activity
Biological process: one-carbon metabolic process
Cellular component: not assigned

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EC 1.14.13.25: Methane monooxygenase (soluble)

Reaction catalysed:
Methane + NAD(P)H + O(2) = methanol + NAD(P)(+) + H(2)O
Systematic name:
Methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)
Alternative Name(s):
  • Methane hydroxylase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02332
Domain description: Methane/Phenol/Alkene Hydroxylase
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
The deposited structure of PDB entry 1xu5 contains 2 copies of Pfam domain PF02332 (Methane/Phenol/Alkene Hydroxylase) in Methane monooxygenase component A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 1xu5 contains 2 copies of Pfam domain PF02332 (Methane/Phenol/Alkene Hydroxylase) in Methane monooxygenase component A beta chain. Showing 1 copy in chain C.

PF02964
Domain description: Methane monooxygenase, hydrolase gamma chain
Occurring in:
  1. Methane monooxygenase component A gamma chain
The deposited structure of PDB entry 1xu5 contains 2 copies of Pfam domain PF02964 (Methane monooxygenase, hydrolase gamma chain) in Methane monooxygenase component A gamma chain. Showing 1 copy in chain E.

InterPro InterPro annotations
IPR004222
Domain description: Methane monooxygenase, gamma chain
Occurring in:
  1. Methane monooxygenase component A gamma chain
IPR012078
Domain description: Methane/phenol monooxygenase, hydroxylase component
Occurring in:
  1. Methane monooxygenase component A beta chain
IPR003430
Domain description: Propane/methane/phenol/toluene hydroxylase
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
IPR009078
Domain description: Ferritin-like superfamily
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
IPR012348
Domain description: Ribonucleotide reductase-like
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
IPR015953
Domain description: Methane monooxygenase, gamma chain, domain 2
Occurring in:
  1. Methane monooxygenase component A gamma chain
IPR015952
Domain description: Methane monooxygenase, gamma chain, domain 1
Occurring in:
  1. Methane monooxygenase component A gamma chain
IPR036123
Domain description: Methane monooxygenase, gamma chain superfamily
Occurring in:
  1. Methane monooxygenase component A gamma chain

Structure domains

CATH CATH domains
1.10.620.20
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase, subunit A
Homology: Ribonucleotide Reductase, subunit A
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
The deposited structure of PDB entry 1xu5 contains 2 copies of CATH domain 1.10.620.20 (Ribonucleotide Reductase, subunit A) in Methane monooxygenase component A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 1xu5 contains 2 copies of CATH domain 1.10.620.20 (Ribonucleotide Reductase, subunit A) in Methane monooxygenase component A beta chain. Showing 1 copy in chain C.
1.20.1280.30
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Monooxygenase
Homology: Methane monooxygenase, gamma chain, domain 2
Occurring in:
  1. Methane monooxygenase component A gamma chain
The deposited structure of PDB entry 1xu5 contains 2 copies of CATH domain 1.20.1280.30 (Monooxygenase) in Methane monooxygenase component A gamma chain. Showing 1 copy in chain E.
1.20.1280.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Monooxygenase
Homology: Methane monooxygenase, gamma chain, domain 1
Occurring in:
  1. Methane monooxygenase component A gamma chain
The deposited structure of PDB entry 1xu5 contains 2 copies of CATH domain 1.20.1280.10 (Monooxygenase) in Methane monooxygenase component A gamma chain. Showing 1 copy in chain E.
SCOP SCOP annotations
47253
Class: All alpha proteins
Fold: Ferritin-like
Superfamily: Ferritin-like
Occurring in:
  1. Methane monooxygenase component A alpha chain
  2. Methane monooxygenase component A beta chain
The deposited structure of PDB entry 1xu5 contains 2 copies of SCOP domain 47253 (Ribonucleotide reductase-like) in Methane monooxygenase component A alpha chain. Showing 1 copy in chain A.
The deposited structure of PDB entry 1xu5 contains 2 copies of SCOP domain 47253 (Ribonucleotide reductase-like) in Methane monooxygenase component A beta chain. Showing 1 copy in chain C.
47153
Class: All alpha proteins
Fold: Open three-helical up-and-down bundle
Superfamily: Methane monooxygenase hydrolase, gamma subunit
Occurring in:
  1. Methane monooxygenase component A gamma chain
The deposited structure of PDB entry 1xu5 contains 2 copies of SCOP domain 47153 (Methane monooxygenase hydrolase, gamma subunit) in Methane monooxygenase component A gamma chain. Showing 1 copy in chain E.

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