› 1xt7

Solution NMR

Daptomycin NMR Structure

Released:
DOI: 10.2210/pdb1xt7/pdb
PDB entry 1xt7 coloured by chain, front view.
PDB entry 1xt7 coloured by chain, side view.
PDB entry 1xt7 coloured by chain, top view.
Source organism: Streptomyces filamentosus
Primary publication:
NMR structure determination and calcium binding effects of lipopeptide antibiotic daptomycin.
Ball LJ, Goult CM, Donarski JA, Micklefield J, Ramesh V
Org Biomol Chem 2 1872-8 (2004)
PMID: 15227539

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162549 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DAPTOMYCIN Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.48 KDa
Source organism: Streptomyces filamentosus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DKA 1 x DKA
6 modified residues:
Ligand DSG 1 x DSG
Ligand ORN 1 x ORN
Ligand DAL 1 x DAL
Ligand DSN 1 x DSN
Ligand LME 1 x LME
Ligand KYN 1 x KYN

Experiments and Validation Details

Entry percentile scores
Refinement method: CONSTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

Quick links

Citations

16 review citations

Natural products to drugs: daptomycin and related lipopeptide antibiotics.
Baltz et al. (2005)
15 more

2 mentions without citation

Daptomycin, a last-resort antibiotic, binds ribosomal protein S19 in humans.
Gotsbacher et al. (2016)
1 more