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The role of modifications in codon discrimination by tRNA(Lys)UUU.

Murphy FV, Ramakrishnan V, Malkiewicz A, Agris PF
Nat Struct Mol Biol 11 1186-91 (2004)
Cited: 210 times
EuropePMC logo PMID: 15558052

Abstract

The natural modification of specific nucleosides in many tRNAs is essential during decoding of mRNA by the ribosome. For example, tRNA(Lys)(UUU) requires the modification N6-threonylcarbamoyladenosine at position 37 (t(6)A37), adjacent and 3' to the anticodon, to bind AAA in the A site of the ribosomal 30S subunit. Moreover, it can only bind both AAA and AAG lysine codons when doubly modified with t(6)A37 and either 5-methylaminomethyluridine or 2-thiouridine at the wobble position (mnm(5)U34 or s(2)U34). Here we report crystal structures of modified tRNA anticodon stem-loops bound to the 30S ribosomal subunit with lysine codons in the A site. These structures allow the rationalization of how modifications in the anticodon loop enable decoding of both lysine codons AAA and AAG.

Reviews - 1xmq mentioned but not cited (1)

  1. Celebrating wobble decoding: Half a century and still much is new. Agris PF, Eruysal ER, Narendran A, Väre VYP, Vangaveti S, Ranganathan SV. RNA Biol 15 537-553 (2018)

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