PDBe 1xmk

X-ray diffraction
0.97Å resolution

The Crystal structure of the Zb domain from the RNA editing enzyme ADAR1

Released:

Function and Biology Details

Reaction catalysed:
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Double-stranded RNA-specific adenosine deaminase Chain: A
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 9.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P55265 (Residues: 294-366; Coverage: 6%)
Gene names: ADAR, ADAR1, DSRAD, G1P1, IFI4
Sequence domains: Adenosine deaminase z-alpha domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 35.557Å b: 43.526Å c: 45.471Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.145 not available 0.183
Expression system: Escherichia coli BL21(DE3)