X-ray diffraction
1.73Å resolution

Crystal structure of human POT1 bound to telomeric single-stranded DNA (TTAGGGTTAG)

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Protection of telomeres protein 1 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q9NUX5 (Residues: 6-299; Coverage: 46%)
Gene name: POT1
Sequence domains: Telomeric single stranded DNA binding POT1/CDC13
Structure domains: Nucleic acid-binding proteins
hT10 d(TTAGGGTTAG) Chain: B
Molecule details ›
Chain: B
Length: 10 nucleotides
Theoretical weight: 3.12 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: C2221
Unit cell:
a: 102.026Å b: 103.243Å c: 71.664Å
α: 90° β: 90° γ: 90°
R R work R free
0.232 0.228 0.237
Expression systems:
  • Spodoptera frugiperda
  • Not provided