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Crystal Structures of Protein Kinase B Selective Inhibitors in Complex with Protein Kinase A and Mutants

X-ray diffraction
2.05Å resolution
PDB entry 1xh5 coloured by chain, front view.
PDB entry 1xh5 coloured by chain, side view.
PDB entry 1xh5 coloured by chain, top view.
Source organisms:
Assembly composition:
monomeric (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-132589
Assembly 2
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Assembly Name: cAMP-dependent protein kinase inhibitor alpha
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-219405

Macromolecules

cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 350 amino acids
Theoretical weight: 40.71 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00517 (Residues: 2-351; Coverage: 100%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
SCOP: Protein kinases, catalytic subunit
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1xh5, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1xh5, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 1xh5, assembly 1, top view.
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cAMP-dependent protein kinase inhibitor alpha
Chain: B
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61925 (Residues: 6-25; Coverage: 26%)
Gene names: PKIA, PRKACN1
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1xh5, assembly 2, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1xh5, assembly 2, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 1xh5, assembly 2, top view.
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