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Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.

Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS
Acta Crystallogr Sect F Struct Biol Cryst Commun 61 459-62 (2005)
Cited: 9 times
EuropePMC logo PMID: 16511068

Abstract

Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.

Articles - 1xe3 mentioned but not cited (3)

  1. Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis. Grenha R, Levdikov VM, Fogg MJ, Blagova EV, Brannigan JA, Wilkinson AJ, Wilson KS. Acta Crystallogr Sect F Struct Biol Cryst Commun 61 459-462 (2005)
  2. Insights into phosphate cooperativity and influence of substrate modifications on binding and catalysis of hexameric purine nucleoside phosphorylases. de Giuseppe PO, Martins NH, Meza AN, dos Santos CR, Pereira HD, Murakami MT. PLoS One 7 e44282 (2012)
  3. Molecular cloning, overexpression, purification, crystallization and preliminary X-ray diffraction analysis of a purine nucleoside phosphorylase from Bacillus subtilis strain 168. Martins NH, Meza AN, Santos CR, de Giuseppe PO, Murakami MT. Acta Crystallogr Sect F Struct Biol Cryst Commun 67 618-622 (2011)


Reviews citing this publication (1)

  1. Inhaled antibiotic-loaded polymeric nanoparticles for the management of lower respiratory tract infections. Rahman Sabuj MZ, Islam N. Nanoscale Adv 3 4005-4018 (2021)

Articles citing this publication (5)

  1. Role of purine biosynthesis in Bacillus anthracis pathogenesis and virulence. Jenkins A, Cote C, Twenhafel N, Merkel T, Bozue J, Welkos S. Infect Immun 79 153-166 (2011)
  2. Crystal structure of Escherichia coli purine nucleoside phosphorylase in complex with 7-deazahypoxanthine. Timofeev VI, Zhukhlistova NE, Abramchik YA, Fateev II, Kostromina MA, Muravieva TI, Esipov RS, Kuranova IP. Acta Crystallogr F Struct Biol Commun 74 355-362 (2018)
  3. Putative vaccine candidates and drug targets identified by reverse vaccinology and subtractive genomics approaches to control Haemophilus ducreyi, the causative agent of chancroid. de Sarom A, Kumar Jaiswal A, Tiwari S, de Castro Oliveira L, Barh D, Azevedo V, Jose Oliveira C, de Castro Soares S. J R Soc Interface 15 20180032 (2018)
  4. Natural Selection in Virulence Genes of Francisella tularensis. Gunnell MK, Robison RA, Adams BJ. J Mol Evol 82 264-278 (2016)
  5. The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a `spanner in the works'. Given FM, Moran F, Johns AS, Titterington JA, Allison TM, Crittenden DL, Johnston JM. Acta Crystallogr F Struct Biol Commun 78 416-422 (2022)


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