› 1xcs

X-ray diffraction
1.4Å resolution

structure of oligonucleotide/drug complex

Released:
DOI: 10.2210/pdb1xcs/pdb
PDB entry 1xcs coloured by chain, front view.
PDB entry 1xcs coloured by chain, side view.
PDB entry 1xcs coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Variable role of ions in two drug intercalation complexes of DNA.
Valls N, Steiner RA, Wright G, Murshudov GN, Subirana JA
J Biol Inorg Chem 10 476-82 (2005)
PMID: 15926069

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114807 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*TP*AP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 6 nucleotides
Theoretical weight: 1.81 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

3 bound ligands:
Ligand CO 2 x CO
Ligand A4L 1 x A4L
Ligand BA 1 x BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: C222
Unit cell:
a: 28.659Å b: 53.473Å c: 40.691Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.193 0.251
Expression system: Not provided

Quick links

Citations

3 citation in other articles

X-ray crystallographic study of DNA duplex cross-linking: simultaneous binding to two d(CGTACG)2 molecules by a bis(9-aminoacridine-4-carboxamide) derivative.
Hopcroft et al. (2006)
2 more