Structure analysis

Crystal Structure of Human Thymidine Kinase 1

X-ray diffraction
2.4Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: homo tetramer

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: homo tetramer
Accessible surface area: 26000 Å2
Buried surface area: 12400 Å2
Dissociation area: 1,700 Å2
Dissociation energy (ΔGdiss): 10 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -98 kcal/mol
Symmetry number: 4

Macromolecules

Chains: A, B, C, D, E, F, G, H
Length: 193 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04183 (Residues: 1-193; Coverage: 83%)
Gene name: TK1
Pfam: Thymidine kinase
InterPro:
CATH:
SCOP:

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