1xbt

X-ray diffraction
2.4Å resolution

Crystal Structure of Human Thymidine Kinase 1

Released:
Source organism: Homo sapiens
Primary publication:
Structures of thymidine kinase 1 of human and mycoplasmic origin.
Proc. Natl. Acad. Sci. U.S.A. 101 17970-5 (2004)
PMID: 15611477

Function and Biology Details

Reaction catalysed:
ATP + thymidine = ADP + thymidine 5'-phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine kinase, cytosolic Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 193 amino acids
Theoretical weight: 21.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04183 (Residues: 1-193; Coverage: 83%)
Gene name: TK1
Sequence domains: Thymidine kinase
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 157.672Å b: 123.177Å c: 116Å
α: 90° β: 130.2° γ: 90°
R-values:
R R work R free
0.203 0.201 0.232
Expression system: Escherichia coli