› 1xav

Solution NMR

Major G-quadruplex structure formed in human c-MYC promoter, a monomeric parallel-stranded quadruplex

Released:
DOI: 10.2210/pdb1xav/pdb
PDB entry 1xav coloured by chain, ensemble of 20 models, front view.
PDB entry 1xav coloured by chain, ensemble of 20 models, side view.
PDB entry 1xav coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
Ambrus A, Chen D, Dai J, Jones RA, Yang D
Biochemistry 44 2048-58 (2005)
PMID: 15697230

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114801 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3' Chain: A
Molecule details ›
Chain: A
Length: 22 nucleotides
Theoretical weight: 7.01 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand K 2 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: molecular dynamics
Expression system: Not provided

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Citations

26 review citations

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?
Balasubramanian et al. (2011)
25 more

69 mentions without citation

Quadruplex DNA: sequence, topology and structure.
Burge et al. (2006)
68 more