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The crystal structure of Pyrococcus furiosus phosphoglucose isomerase with bound 5-phospho-D-arabinonate and Manganese

Source organism: Pyrococcus furiosus
Biochemical function: metal ion binding
Biological process: glycolytic process
Cellular component: cytoplasm

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EC 5.3.1.9: Glucose-6-phosphate isomerase

Reaction catalysed:
Alpha-D-glucose 6-phosphate = beta-D-fructofuranose 6-phosphate
Systematic name:
Alpha-D-glucose-6-phosphate aldose-ketose-isomerase (configuration-inverting)
Alternative Name(s):
  • D-glucose-6-phosphate ketol-isomerase
  • Glucose phosphate isomerase
  • Hexose monophosphate isomerase
  • Hexose phosphate isomerase
  • Hexosephosphate isomerase
  • Oxoisomerase
  • Phosphoglucoisomerase
  • Phosphoglucose isomerase
  • Phosphohexoisomerase
  • Phosphohexomutase
  • Phosphohexose isomerase
  • Phosphosaccharomutase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF06560
Domain description: Glucose-6-phosphate isomerase (GPI)
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1x7n contains 1 copy of Pfam domain PF06560 (Glucose-6-phosphate isomerase (GPI)) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR016758
Domain description: Glucose-6-phosphate isomerase, archaea/bacteria
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR010551
Domain description: Glucose-6-phosphate isomerase, prokaryote
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR014710
Domain description: RmlC-like jelly roll fold
Occurring in:
  1. Glucose-6-phosphate isomerase
IPR011051
Domain description: RmlC-like cupin domain superfamily
Occurring in:
  1. Glucose-6-phosphate isomerase

Structure domain

CATH CATH domain
2.60.120.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1x7n contains 1 copy of CATH domain 2.60.120.10 (Jelly Rolls) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.
SCOP SCOP annotation
89403
Class: All beta proteins
Fold: Double-stranded beta-helix
Superfamily: RmlC-like cupins
Occurring in:
  1. Glucose-6-phosphate isomerase
The deposited structure of PDB entry 1x7n contains 1 copy of SCOP domain 89403 (Glucose-6-phosphate isomerase, GPI) in Glucose-6-phosphate isomerase. Showing 1 copy in chain A.

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