1x49

Solution NMR

Solution structure of the first DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase

Released:
Source organism: Mus musculus
Entry authors: He F, Muto Y, Inoue M, Kigawa T, Shirouzu M, Terada T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-induced, double-stranded RNA-activated protein kinase Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 10.58 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q03963 (Residues: 1-84; Coverage: 16%)
Gene names: Eif2ak2, Pkr, Prkr, Tik
Sequence domains: Double-stranded RNA binding motif
Structure domains: Double Stranded RNA Binding Domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided