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Crystal Structure of Lipate-Protein Ligase A from Escherichia coli

Source organism: Escherichia coli
Biochemical function: lipoyltransferase activity
Biological process: protein modification process
Cellular component: cytosol

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EC 6.3.1.20: Lipoate--protein ligase

Reaction catalysed:
(1a) ATP + (R)-lipoate = lipoyl-AMP + diphosphate
Systematic name:
[Lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming)
Alternative Name(s):
  • LPL
  • LPL-B
  • Lipoate protein ligase
  • Lipoate-protein ligase A
  • LplA (gene name)
  • LplJ (gene name)

GO terms

Sequence families

Pfam Protein families (Pfam)
PF10437
Domain description: Bacterial lipoate protein ligase C-terminus
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of Pfam domain PF10437 (Bacterial lipoate protein ligase C-terminus) in Lipoate-protein ligase A. Showing 1 copy in chain C.

PF03099
Domain description: Biotin/lipoate A/B protein ligase family
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of Pfam domain PF03099 (Biotin/lipoate A/B protein ligase family) in Lipoate-protein ligase A. Showing 1 copy in chain C.

InterPro InterPro annotations
IPR004143
Domain description: Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain
Occurring in:
  1. Lipoate-protein ligase A
IPR004562
Domain description: Lipoyltransferase/lipoate-protein ligase
Occurring in:
  1. Lipoate-protein ligase A
IPR045864
Domain description: Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
Occurring in:
  1. Lipoate-protein ligase A
IPR019491
Domain description: Lipoate protein ligase, C-terminal
Occurring in:
  1. Lipoate-protein ligase A
IPR023741
Domain description: Lipoate-protein ligase A
Occurring in:
  1. Lipoate-protein ligase A

Structure domains

CATH CATH domains
3.30.390.50
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: CO dehydrogenase flavoprotein, C-terminal domain
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of CATH domain 3.30.390.50 (Enolase-like; domain 1) in Lipoate-protein ligase A. Showing 1 copy in chain C.
3.30.930.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: BirA Bifunctional Protein; domain 2
Homology: Bira Bifunctional Protein; Domain 2
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of CATH domain 3.30.930.10 (BirA Bifunctional Protein; domain 2) in Lipoate-protein ligase A. Showing 1 copy in chain C.
SCOP SCOP annotations
143216
Class: Alpha and beta proteins (a+b)
Fold: SufE/NifU
Superfamily: SufE/NifU
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of SCOP domain 143216 (SP1160 C-terminal domain-like) in Lipoate-protein ligase A. Showing 1 copy in chain C.
143642
Class: Alpha and beta proteins (a+b)
Fold: Class II aaRS and biotin synthetases
Superfamily: Class II aaRS and biotin synthetases
Occurring in:
  1. Lipoate-protein ligase A
The deposited structure of PDB entry 1x2g contains 3 copies of SCOP domain 143642 (LplA-like) in Lipoate-protein ligase A. Showing 1 copy in chain C.

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