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Human Factor Viia-Tissue Factor in Complex with peptide-mimetic inhibitor that has two charged groups in P2 and P4

X-ray diffraction
2.6Å resolution
PDB entry 1wss coloured by chain, front view.
PDB entry 1wss coloured by chain, side view.
PDB entry 1wss coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Coagulation factor VIIa - tissue factor complex
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Multimeric state: hetero trimer
Accessible surface area: 27458.84 Å2
Buried surface area: 8032.71 Å2
Dissociation area: 2,903.21 Å2
Dissociation energy (ΔGdiss): 6.22 kcal/mol
Dissociation entropy (TΔSdiss): 26.03 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140352
Complex Portal ID: CPX-2808

Macromolecules

Factor VII light chain
Chain: L
Length: 152 amino acids
Theoretical weight: 17.49 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08709 (Residues: 61-212; Coverage: 34%)
Gene name: F7
Pfam:
InterPro:
SCOP:
Factor VII light chain in PDB entry 1wss, assembly 1, front view.
Factor VII light chain in PDB entry 1wss, assembly 1, side view.
Factor VII light chain in PDB entry 1wss, assembly 1, top view.
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Factor VII heavy chain
Chain: H
Length: 254 amino acids
Theoretical weight: 28.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P08709 (Residues: 213-466; Coverage: 57%)
Gene name: F7
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases
SCOP: Eukaryotic proteases
Factor VII heavy chain in PDB entry 1wss, assembly 1, front view.
Factor VII heavy chain in PDB entry 1wss, assembly 1, side view.
Factor VII heavy chain in PDB entry 1wss, assembly 1, top view.
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Tissue factor
Chain: T
Length: 218 amino acids
Theoretical weight: 24.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P13726 (Residues: 33-250; Coverage: 83%)
Gene name: F3
Pfam:
InterPro:
CATH: Immunoglobulins
SCOP: Fibronectin type III
Tissue factor in PDB entry 1wss, assembly 1, front view.
Tissue factor in PDB entry 1wss, assembly 1, side view.
Tissue factor in PDB entry 1wss, assembly 1, top view.
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