Function and Biology Details
Reaction catalysed:
3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
- 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain
- 6-phosphogluconate dehydrogenase, domain 2
- 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
- 3-hydroxyisobutyrate dehydrogenase-related, conserved site
- NAD(P)-binding domain superfamily
- 6-phosphogluconate dehydrogenase, NADP-binding
- 3-hydroxyisobutyrate dehydrogenase-related
Structure analysis Details
Assembly composition:
homo tetramer (preferred)
Assembly name:
3-hydroxyisobutyrate dehydrogenase (preferred)
PDBe Complex ID:
PDB-CPX-178204 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-hydroxyisobutyrate dehydrogenase
Molecule details ›
Chains: A, B, C, D
Length: 289 amino acids
Theoretical weight: 31.38 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
Sequence domains:
Length: 289 amino acids
Theoretical weight: 31.38 KDa
Source organism: Thermus thermophilus HB8
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
Q5SLQ6 (Residues: 1-289; Coverage: 100%)
Sequence domains:
- NAD binding domain of 6-phosphogluconate dehydrogenase
- NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
