PDBe 1wnt

X-ray diffraction
2.3Å resolution

Strucutre of the tetrameric form of Human L-Xylulose Reductase

Released:

Function and Biology Details

Reaction catalysed:
Xylitol + NADP(+) = L-xylulose + NADPH
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-xylulose reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 244 amino acids
Theoretical weight: 25.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q7Z4W1 (Residues: 1-244; Coverage: 100%)
Gene names: DCXR, SDR20C1
Sequence domains: Enoyl-(Acyl carrier protein) reductase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 4 x NAP
No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 81.941Å b: 59.96Å c: 82.805Å
α: 90° β: 91.678° γ: 90°
R-values:
R R work R free
0.32 0.202 0.252
Expression system: Escherichia coli BL21