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Crystal structure of the ternary complex of eIF4E-m7GpppA-4EBP1 peptide

Source organism: Homo sapiens
Biochemical function: eukaryotic initiation factor 4E binding
Biological process: negative regulation of translational initiation
Cellular component: cytoplasm

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GO terms

Sequence family

Pfam Protein family (Pfam)
PF01652
Domain description: Eukaryotic initiation factor 4E
Occurring in:
  1. Eukaryotic translation initiation factor 4E
The deposited structure of PDB entry 1wkw contains 1 copy of Pfam domain PF01652 (Eukaryotic initiation factor 4E) in Eukaryotic translation initiation factor 4E. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001040
Domain description: Translation Initiation factor eIF- 4e
Occurring in:
  1. Eukaryotic translation initiation factor 4E
IPR023398
Domain description: Translation Initiation factor eIF- 4e-like
Occurring in:
  1. Eukaryotic translation initiation factor 4E
IPR008606
Domain description: Eukaryotic translation initiation factor 4E binding
Occurring in:
  1. Eukaryotic translation initiation factor 4E-binding protein 1
IPR019770
Domain description: Eukaryotic translation initiation factor 4E (eIF-4E), conserved site
Occurring in:
  1. Eukaryotic translation initiation factor 4E

Structure domain

CATH CATH domain
3.30.760.10
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: RNA Cap, Translation Initiation Factor Eif4e
Homology: RNA Cap, Translation Initiation Factor Eif4e
Occurring in:
  1. Eukaryotic translation initiation factor 4E
The deposited structure of PDB entry 1wkw contains 1 copy of CATH domain 3.30.760.10 (RNA Cap, Translation Initiation Factor Eif4e) in Eukaryotic translation initiation factor 4E. Showing 1 copy in chain A.
SCOP SCOP annotation
55419
Class: Alpha and beta proteins (a+b)
Fold: eIF4e-like
Superfamily: eIF4e-like
Occurring in:
  1. Eukaryotic translation initiation factor 4E
The deposited structure of PDB entry 1wkw contains 1 copy of SCOP domain 55419 (Translation initiation factor eIF4e) in Eukaryotic translation initiation factor 4E. Showing 1 copy in chain A.

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