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Structural basis for non-cognate amino acid discrimination by the valyl-tRNA synthetase editing domain

Source organism: Thermus thermophilus
Biochemical function: ATP binding
Biological process: valyl-tRNA aminoacylation
Cellular component: not assigned

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EC 6.1.1.9: Valine--tRNA ligase

Reaction catalysed:
ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)
Systematic name:
L-valine:tRNA(Val) ligase (AMP-forming)
Alternative Name(s):
  • Valine transfer ribonucleate ligase
  • Valine translase
  • Valyl-tRNA synthetase
  • Valyl-transfer RNA synthetase
  • Valyl-transfer ribonucleate synthetase
  • Valyl-transfer ribonucleic acid synthetase

GO terms

Sequence family

InterPro InterPro annotations
IPR009008
Domain description: Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Occurring in:
  1. Valine--tRNA ligase
IPR002300
Domain description: Aminoacyl-tRNA synthetase, class Ia
Occurring in:
  1. Valine--tRNA ligase
IPR002303
Domain description: Valine-tRNA ligase
Occurring in:
  1. Valine--tRNA ligase

Structure domain

CATH CATH domain
3.90.740.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Isoleucyl-tRNA Synthetase; domain 2
Homology: Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain
Occurring in:
  1. Valine--tRNA ligase
The deposited structure of PDB entry 1wk9 contains 1 copy of CATH domain 3.90.740.10 (Isoleucyl-tRNA Synthetase; domain 2) in Valine--tRNA ligase. Showing 1 copy in chain A.
SCOP SCOP annotation
50678
Class: All beta proteins
Fold: ValRS/IleRS/LeuRS editing domain
Superfamily: ValRS/IleRS/LeuRS editing domain
Occurring in:
  1. Valine--tRNA ligase
The deposited structure of PDB entry 1wk9 contains 1 copy of SCOP domain 50678 (ValRS/IleRS/LeuRS editing domain) in Valine--tRNA ligase. Showing 1 copy in chain A.

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