Structure analysis

wildtype tryptophan synthase complexed with glycerol phosphate

X-ray diffraction
1.5Å resolution
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero tetramer
Accessible surface area: 43300 Å2
Buried surface area: 10800 Å2
Dissociation area: 1,600 Å2
Dissociation energy (ΔGdiss): 11 kcal/mol
Dissociation entropy (TΔSdiss): 15 kcal/mol
Interface energy (ΔGint): -72 kcal/mol
Symmetry number: 2

Macromolecules

Chain: A
Length: 268 amino acids
Theoretical weight: 28.7 KDa
Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Expression system: Escherichia coli
UniProt:
  • Canonical: P00929 (Residues: 1-268; Coverage: 100%)
Gene names: STM1727, trpA
Pfam: Tryptophan synthase alpha chain
InterPro:
CATH: Aldolase class I
SCOP: Tryptophan biosynthesis enzymes

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