› 1wao

X-ray diffraction
2.9Å resolution

PP5 structure

Released:
DOI: 10.2210/pdb1wao/pdb
PDB entry 1wao coloured by chain, front view.
PDB entry 1wao coloured by chain, side view.
PDB entry 1wao coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
Yang J, Roe SM, Cliff MJ, Williams MA, Ladbury JE, Cohen PT, Barford D
EMBO J 24 1-10 (2005)
PMID: 15577939

Function and Biology Details

Reaction catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 5 Chains: 1, 2, 3, 4
Molecule details ›
Chains: 1, 2, 3, 4
Length: 477 amino acids
Theoretical weight: 54.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53041 (Residues: 23-499; Coverage: 96%)
Gene names: PPP5, PPP5C
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 8 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 51.74Å b: 117.54Å c: 200.41Å
α: 90° β: 93.79° γ: 90°
R-values:
R R work R free
0.247 0.247 0.29
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Serine/threonine phosphatases: mechanism through structure.
Shi Y. (2009)
20 more

17 mentions without citation

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.
Golden et al. (2008)
16 more