› 1w8k

X-ray diffraction
1.8Å resolution

Crystal structure of apical membrane antigen 1 from Plasmodium vivax

Released:
DOI: 10.2210/pdb1w8k/pdb
PDB 1w8k coloured by chain and viewed from the front.
PDB 1w8k coloured by chain and viewed from the side.
PDB 1w8k coloured by chain and viewed from the top.
Source organism: Plasmodium vivax
Primary publication:
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA
Science 308 408-11 (2005)
PMID: 15731407

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical merozoite antigen 1 Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 51.6 KDa
Source organism: Plasmodium vivax
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O61130 (Residues: 43-487; Coverage: 79%)
Gene name: AMA1
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

1 bound ligand:
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 150.03Å b: 53.76Å c: 60.29Å
α: 90° β: 113.18° γ: 90°
R-values:
R R work R free
0.222 0.219 0.269
Expression system: Komagataella pastoris

Quick links

Citations

23 review citations

Progress towards the development of a P. vivax vaccine.
De et al. (2021)
22 more

15 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
14 more