Function and Biology

Binary structure of human DECR.

Source organism: Homo sapiens
Biochemical function: oxidoreductase activity
Biological process: positive regulation of cold-induced thermogenesis
Cellular component: cytosol

EC 1.3.1.34: 2,4-dienoyl-CoA reductase ((2E)-enoyl-CoA-producing)

Reaction catalysed:
A (2E)-2-enoyl-CoA + NADP(+) = a (2E,4E)-2,4-dienoyl-CoA + NADPH
Systematic name:
(2E)-2-enoyl-CoA:NADP(+) 4-oxidoreductase
Alternative Name(s):
  • 2,4-dienoyl-CoA reductase (NADPH)
  • 4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase
  • 4-enoyl-CoA reductase
  • 4-enoyl-CoA reductase (NADPH(2))
  • 4-enoyl-CoA reductase (NADPH)

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
1 copy of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial in PDB 1w8d.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
1 copy of CATH domain 3.40.50.720 (Rossmann fold) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial in PDB 1w8d.
SCOP SCOP annotation
51751
Class: Alpha and beta proteins (a/b)
Fold: NAD(P)-binding Rossmann-fold domains
Superfamily: NAD(P)-binding Rossmann-fold domains
Occurring in:
  1. 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial
1 copy of SCOP domain 51751 (Tyrosine-dependent oxidoreductases) in 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial in PDB 1w8d.